NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression.

@article{Yang2009NADPHO2,
  title={NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression.},
  author={Chul-Su Yang and Dong-Min Shin and Ki-Hye Kim and Z N Lee and Chul-Ho Lee and Sung Goo Park and Yun Soo Bae and Eun Kyeong Jo},
  journal={Journal of immunology},
  year={2009},
  volume={182 6},
  pages={3696-705}
}
Gp91(phox)/NADPH oxidase (NOX) 2 is the main catalytic component of NOX, which mediates the phagocytic killing of ingested pathogens via the production of reactive oxygen species (ROS). However, Mycobacterium tuberculosis (Mtb) is relatively resistant to the microbicidal effects of ROS. Thus, the exact roles of NOX2 in the innate immune control against Mtb infection are not fully resolved. In this study, we show that NOX2 is essential for TLR2-dependent inflammatory responses and 1,25… CONTINUE READING
65 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

Similar Papers

Loading similar papers…