NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.

@article{Kim2010NADPHO2,
  title={NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.},
  author={Donghoon Kim and Byunghyun You and Eun Kyeong Jo and Sang-kyou Han and Melvin I. Simon and Sung Joong Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 33},
  pages={14851-6}
}
Increasing evidence supports the notion that spinal cord microglia activation plays a causal role in the development of neuropathic pain after peripheral nerve injury; yet the mechanisms for microglia activation remain elusive. Here, we provide evidence that NADPH oxidase 2 (Nox2)-derived ROS production plays a critical role in nerve injury-induced spinal cord microglia activation and subsequent pain hypersensitivity. Nox2 expression was induced in dorsal horn microglia immediately after L5… CONTINUE READING