NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.

  title={NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.},
  author={St{\'e}phanie Carnesecchi and Christine Deffert and Alessandra Pagano and Sarah Garrido-Urbani and Isabelle M{\'e}trailler-Ruchonnet and Michela G. Sch{\"a}ppi and Y. R. A. Donati and Michael A. Matthay and K T Krause and Constance Barazzone Argiroffo},
  journal={American journal of respiratory and critical care medicine},
  volume={180 10},
RATIONALE Hyperoxia-induced acute lung injury has been used for many years as a model of oxidative stress mimicking clinical acute lung injury and the acute respiratory distress syndrome. Excess quantities of reactive oxygen species (ROS) are responsible for oxidative stress-induced lung injury. ROS are produced by mitochondrial chain transport, but also by NADPH oxidase (NOX) family members. Although NOX1 and NOX2 are expressed in the lungs, their precise function has not been determined until… CONTINUE READING


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NOX enzymes and the biology of reactive oxygen

Nature Reviews Immunology • 2004
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NADPH oxidase (NOX1) is essential in hyperoxia-induced lung damage [abstract

S Carnesecchi, C Deffert, +5 authors C. Barazzone-Argiroffo
Am J Respir Crit Care Med 2009;179:A5364 • 2009
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