NADPH generating enzymes in Leydig cells from diabetic rats.

  title={NADPH generating enzymes in Leydig cells from diabetic rats.},
  author={J. Carlos Calvo and L Biella de Souza Valle and Jos{\'e} Lino Bara{\~n}ao and Marta Tesone and Eduardo Hern{\'a}n Charreau},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={11 2},
Impaired testosterone biosynthesis in Leydig cells from streptozotocin treated rats is correlated with the reduced activity of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and isocitrate dehydrogenase. The results shown demonstrate that in the diabetic state the activity of these enzymes is reduced by almost 50 to 59% from normal levels. Insulin treatment restored their activities to normal levels. The diminished supply of NADPH in diabetic interstitial tissue is not the… CONTINUE READING

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