NADPH and “cocktails” containing polyarginine reactivate superoxide generation in leukocytes lysed by membrane-damaging agents

Human blood leukocytes generated large amounts of superoxide O2 − following stimulation by certain “cocktails” of soluble agents consisting of poly-L-arginine (PARG), phytohemagglutinin, the chemotactic peptide formylmethionyl-leucyl-phenylalanine and polyanethole sulfanote (liquoid). A variety of cytochalasins, which markedly boosted O2 − generation by the… CONTINUE READING