NADPH Oxidase-Driven Phagocyte Recruitment Controls Candida albicans Filamentous Growth and Prevents Mortality

@inproceedings{Brothers2013NADPHOP,
  title={NADPH Oxidase-Driven Phagocyte Recruitment Controls Candida albicans Filamentous Growth and Prevents Mortality},
  author={Kimberly M. Brothers and Remi L. Gratacap and Sarah E. Barker and Zachary R. Newman and Ashley E. Norum and Robert T Wheeler},
  booktitle={PLoS pathogens},
  year={2013}
}
Candida albicans is a human commensal and clinically important fungal pathogen that grows as both yeast and hyphal forms during human, mouse and zebrafish infection. Reactive oxygen species (ROS) produced by NADPH oxidases play diverse roles in immunity, including their long-appreciated function as microbicidal oxidants. Here we demonstrate a non-traditional mechanistic role of NADPH oxidase in promoting phagocyte chemotaxis and intracellular containment of fungi to limit filamentous growth. We… CONTINUE READING
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