NADP, corepressor for the Bacillus catabolite control protein CcpA.

@article{Kim1998NADPCF,
  title={NADP, corepressor for the Bacillus catabolite control protein CcpA.},
  author={Junghoon Kim and Martin I. Voskuil and Glenn H. Chambliss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 16},
  pages={9590-5}
}
Expression of the alpha-amylase gene (amyE) of Bacillus subtilis is subject to CcpA (catabolite control protein A)-mediated catabolite repression, a global regulatory mechanism in Bacillus and other Gram-positive bacteria. To determine effectors of CcpA, we tested the ability of glycolytic metabolites, nucleotides, and cofactors to affect CcpA binding to the amyE operator, amyO. Those that stimulated the DNA-binding affinity of CcpA were tested for their effect on transcription. HPr-P (Ser-46… CONTINUE READING