NADH supplementation decreases pinacidil‐primed IK(ATP) in ventricular cardiomyocytes by increasing intracellular ATP

@article{Pelzmann2003NADHSD,
  title={NADH supplementation decreases pinacidil‐primed IK(ATP) in ventricular cardiomyocytes by increasing intracellular ATP},
  author={Brigitte Pelzmann and Seth Hallstr{\"o}m and Peter Schaffer and Petra Lang and Karl Nadlinger and Georg Dr Birkmayer and Karoline Vrecko and Gilbert Reibnegger and Bernd Koidl},
  journal={British Journal of Pharmacology},
  year={2003},
  volume={139}
}
The aim of this study was to investigate the effect of nicotinamide‐adenine dinucleotide (NADH) supplementation on the metabolic condition of isolated guinea‐pig ventricular cardiomyocytes. The pinacidil‐primed ATP‐dependent potassium current IK(ATP) was used as an indicator of subsarcolemmal ATP concentration and intracellular adenine nucleotide contents were measured. Membrane currents were studied using the patch‐clamp technique in the whole‐cell recording mode at 36–37°C. Adenine… 
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