NADH- and NADPH-linked aquacobalamin reductases occur in both mitochondrial and microsomal membranes of rat liver.

@article{Watanabe1989NADHAN,
  title={NADH- and NADPH-linked aquacobalamin reductases occur in both mitochondrial and microsomal membranes of rat liver.},
  author={Fumio Watanabe and Yoshihisa Nakano and Susumu Maruno and N Tachikake and Youjiro Tamura and Shozaburo Kitaoka},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={165 2},
  pages={675-9}
}
To elucidate the mechanism for the synthesis of the coenzyme forms of cobalamin in mammals, rat liver aquacobalamin reductase was partially characterized. Rat liver contained both NADH- and NADPH-linked aquacobalamin reductases. The NADH-linked enzyme was distributed in the mitochondria (approx. 40%) and microsomes (60%), identical to the distribution of the NADPH-linked enzyme. The two mitochondrial NADH- and NADPH-linked enzymes were located inside of the outer membrane. 

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