NAD metabolism fuels human and mouse intestinal inflammation

  title={NAD metabolism fuels human and mouse intestinal inflammation},
  author={Romana Raphaela Gerner and Victoria Klepsch and Sophie Macheiner and Kathrin Arnhard and Timon Erik Adolph and Christoph Grander and Verena Wieser and Alexandra Bloch Pfister and Patrizia Lucia Moser and Natascha Hermann-Kleiter and Gottfried Baier and Herbert Oberacher and Herbert Tilg and Alexander R Moschen},
OBJECTIVE Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing the rate-limiting step of the NAD salvage pathway. NAMPT is strongly upregulated in inflammation including IBD and counteracts an increased cellular NAD turnover mediated by NAD-depleting enzymes. These constitute an important mechanistic link between… CONTINUE READING
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