NAD glycohydrolase specifically induced by retinoic acid in human leukemic HL-60 cells. Identification of the NAD glycohydrolase as leukocyte cell surface antigen CD38.

Abstract

Human leukemic HL-60 cells are differentiated into granulocytic cells by retinoic acid, and this differentiation is preceded by the induction of an ecto-enzyme of NAD glycohydrolase (NADase). The NADase specifically induced by retinoic acid appeared to be encoded by human leukocyte cell surface antigen CD38 as follows. 1) There was an early expression of… (More)

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