NAD glycohydrolase activities and ADP-ribose uptake in erythrocytes from normal subjects and cancer patients.

@article{Albeniz2004NADGA,
  title={NAD glycohydrolase activities and ADP-ribose uptake in erythrocytes from normal subjects and cancer patients.},
  author={Işil Albeni̇z and O. Koray Demir and R{\"u}stem Nurten and Engin Bermek},
  journal={Bioscience reports},
  year={2004},
  volume={24 1},
  pages={
          41-53
        }
}
Erythrocytes from cancer patients exhibited up to fivefold higher NAD glycohydrolase activities than control erythrocytes from normal subjects and also similarly increased [14C] ADP-ribose uptake values. When [adenosine-14C] NAD was used instead of free [14C] ADP-ribose, the uptake was dependent on ecto-NAD glycohydrolase activity. This was reflected in the inhibition of ADP-ribose uptake from [adenosine-14C] NAD by Cibacron Blue. ADP-ribose uptake in erythrocytes appeared to be complex: upon… CONTINUE READING

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