NAD depletion after in vitro exposure of murine lung slices to bleomycin.

@article{Hoyt1993NADDA,
  title={NAD depletion after in vitro exposure of murine lung slices to bleomycin.},
  author={Dale G. Hoyt and John S Lazo},
  journal={Biochemical pharmacology},
  year={1993},
  volume={46 10},
  pages={1819-24}
}
Bleomycin (BLM), a DNA-cleaving, antitumor antibiotic, causes pulmonary fibrosis. It also causes cell injury and activates the nuclear enzyme poly(ADP-ribose) polymerase (PAP; EC 2.4.2.30) in lung slices exposed to the drug in vitro. 3-Aminobenzamide (3-AB), a PAP inhibitor, prevents enzyme activation and cell injury. We have examined the potential role of ATP and NAD depletion in injury of BLM-sensitive C57B1/6N and -resistant BALB/cN murine lung slices treated with BLM or deprived of glucose… CONTINUE READING