NAD + biosynthesis, aging, and disease

+ biosynthesis, aging, and disease},
  author={Sean Johnson and Shin-ichiro Imai},
Nicotinamide adenine dinucleotide (NAD +) biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD + across multiple tissues. The dysfunction of NAD + biosynthesis plays a critical role in the pathophysiologies of multiple diseases, including age-associated metabolic disorders, neurodegenerative diseases, and mental disorders. As downstream effectors, NAD +-dependent enzymes, such as sirtuins, are involved in the… CONTINUE READING
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