Corpus ID: 33536653

NAD(P)H oxidases regulate HIF-2alpha protein expression.

  title={NAD(P)H oxidases regulate HIF-2alpha protein expression.},
  author={K. Block and Y. Gorin and P. Hoover and P. Williams and Tomasz Chelmicki and R. Clark and T. Yoneda and H. Abboud},
  journal={The Journal of biological chemistry},
  volume={282 11},
Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) is linked to the development of hereditary and sporadic renal cell carcinoma (RCC). In the absence of VHL, the alpha subunits of heterodimeric hypoxia-inducible transcription factors (HIF-1alpha and HIF-2alpha) are stabilized. Reactive oxygen species, generated by NAD(P)H oxidases, are involved in signaling cascades of malignant growth. We show that in VHL-deficient cells p22phox, Nox4 protein levels and NADPH-dependent… Expand
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