NAD+ in aging, metabolism, and neurodegeneration

@article{Verdin2015NADIA,
  title={NAD+ in aging, metabolism, and neurodegeneration},
  author={Eric Verdin},
  journal={Science},
  year={2015},
  volume={350},
  pages={1208 - 1213}
}
  • E. Verdin
  • Published 4 December 2015
  • Biology
  • Science
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate–ribose) polymerases. Cellular NAD+ concentrations change during aging, and modulation of NAD+ usage or production can prolong both health span and life span. Here we review factors that… 

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References

SHOWING 1-10 OF 116 REFERENCES

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

TLDR
The results are the first to show a significant decline in intracellular NAD+ levels and NAD∶NADH ratio in all organs by middle age compared to young rats, and suggest that adequate NAD+ concentrations may be an important longevity assurance factor.

Physiological and pathophysiological roles of NAMPT and NAD metabolism

TLDR
NAMPT is able to modulate processes involved in the pathogenesis of obesity and related disorders by influencing the oxidative stress response, apoptosis, lipid and glucose metabolism, inflammation and insulin resistance, and is an experimental target for antitumour therapies.

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

Nicotinamide adenine dinucleotide (NAD+) is an essential electron transporter in mitochondrial respiration and oxidative phosphorylation. In genomic DNA, NAD+ also represents the sole substrate for

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.

TLDR
An integrated view on the pathways that control NAD(+) production and cycling, as well as its cellular compartmentalization, and novel data that show how modulation of NAD(+)-producing and -consuming pathways have a major physiological impact and hold promise for the prevention and treatment of metabolic disease are provided.
...