NAD+ in aging, metabolism, and neurodegeneration

  title={NAD+ in aging, metabolism, and neurodegeneration},
  author={Eric Verdin},
  pages={1208 - 1213}
  • E. Verdin
  • Published 4 December 2015
  • Biology
  • Science
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate–ribose) polymerases. Cellular NAD+ concentrations change during aging, and modulation of NAD+ usage or production can prolong both health span and life span. Here we review factors that… 

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