NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.

@article{Yang2010NADdependentDS,
  title={NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.},
  author={Yongjie Yang and Huseyin Cimen and M Han and Tong Shun Shi and J Deng and Hasan Koc and Orsolya M. Palacios and Laura Montier and Yidong Bai and Qiang Tong and Emine Koç},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 10},
  pages={7417-29}
}
A member of the sirtuin family of NAD(+)-dependent deacetylases, SIRT3, is located in mammalian mitochondria and is important for regulation of mitochondrial metabolism, cell survival, and longevity. In this study, MRPL10 (mitochondrial ribosomal protein L10) was identified as the major acetylated protein in the mitochondrial ribosome. Ribosome-associated SIRT3 was found to be responsible for deacetylation of MRPL10 in an NAD(+)-dependent manner. We mapped the acetylated Lys residues by tandem… CONTINUE READING