NAD+ as a signaling molecule modulating metabolism.

  title={NAD+ as a signaling molecule modulating metabolism.},
  author={Carles Cant{\'o} and Johan Auwerx},
  journal={Cold Spring Harbor symposia on quantitative biology},
The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular… CONTINUE READING

From This Paper

Topics from this paper.
34 Citations
97 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 34 extracted citations


Publications referenced by this paper.
Showing 1-10 of 97 references

Similar Papers

Loading similar papers…