NAD+ as a signaling molecule modulating metabolism.

@article{Cant2011NADAA,
  title={NAD+ as a signaling molecule modulating metabolism.},
  author={Carles Cant{\'o} and Johan Auwerx},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2011},
  volume={76},
  pages={291-8}
}
The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular… CONTINUE READING

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