NAD+ and sirtuins in aging and disease.

  title={NAD+ and sirtuins in aging and disease.},
  author={Shin-ichiro Imai and Leonard P. Guarente},
  journal={Trends in cell biology},
  volume={24 8},
Nicotinamide adenine dinucleotide (NAD(+)) is a classical coenzyme mediating many redox reactions. NAD(+) also plays an important role in the regulation of NAD(+)-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD(+) biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD(+) levels decline during the aging process and may be an… CONTINUE READING
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