NAD+ and Vitamin B3: From Metabolism to Therapies

  title={NAD+ and Vitamin B3: From Metabolism to Therapies},
  author={Anthony A Sauve},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={883 - 893}
  • A. Sauve
  • Published 1 March 2008
  • Biology
  • Journal of Pharmacology and Experimental Therapeutics
The role of NAD+ metabolism in health and disease is of increased interest as the use of niacin (nicotinic acid) has emerged as a major therapy for treatment of hyperlipidemias and with the recognition that nicotinamide can protect tissues and NAD+ metabolism in a variety of disease states, including ischemia/reperfusion. In addition, a growing body of evidence supports the view that NAD+ metabolism regulates important biological effects, including lifespan. NAD+ exerts potent effects through… 

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