NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.

@article{Harkcom2014NADAS,
  title={NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.},
  author={William T Harkcom and Ananda K. Ghosh and Matthew S Sung and Alexandre Matov and Kevin Brown and Paraskevi Giannakakou and Samie R. Jaffrey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 24},
  pages={E2443-52}
}
Nicotinamide adenine dinucleotide (NAD(+)) is an endogenous enzyme cofactor and cosubstrate that has effects on diverse cellular and physiologic processes, including reactive oxygen species generation, mitochondrial function, apoptosis, and axonal degeneration. A major goal is to identify the NAD(+)-regulated cellular pathways that may mediate these effects. Here we show that the dynamic assembly and disassembly of microtubules is markedly altered by NAD(+). Furthermore, we show that the… CONTINUE READING
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Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics

  • JB Long
  • Mol Cell Biol
  • 2013
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