NAD(P)H oxidases and their relevance to atherosclerosis.

  title={NAD(P)H oxidases and their relevance to atherosclerosis.},
  author={Dan Sorescu and Katalin Szoecs and Kathy K. Griendling},
  journal={Trends in cardiovascular medicine},
  volume={11 3-4},
Studies performed during the last decade have identified NAD(P)H oxidases unique to nonphagocytic vascular cells. The reactive oxygen species released from these enzymes regulate fundamental cellular functions such as growth (hyperplastic or hypertrophic), endothelial dysfunction, migration and inflammation, which have been demonstrated to play a role in atherogenesis. Evidence from experimental animal and human studies implicate the nonphagocytic NAD(P)H oxidases in multiple aspects of… CONTINUE READING