NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts.

@article{Bondi2010NADPHOM,
  title={NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts.},
  author={Corry D Bondi and Nagaraj Manickam and Duck Yoon Lee and Karen L. Block and Yves C Gorin and Hanna Emily Abboud and Jeffrey L. Barnes},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2010},
  volume={21 1},
  pages={93-102}
}
TGF-beta1 expression closely associates with activation and conversion of fibroblasts to a myofibroblast phenotype and synthesis of an alternatively spliced cellular fibronectin variant, Fn-ED-A. Reactive oxygen species (ROS), such as superoxide, which is a product of NAD(P)H oxidase, also promote the transition of fibroblasts to myofibroblasts, but whether these two pathways are interrelated is unknown. Here, we examined a role for NAD(P)H oxidase-derived ROS in TGF-beta1-induced activation of… CONTINUE READING
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