NAD(P)H oxidase inhibition attenuates neuronal chronotropic actions of angiotensin II.

@article{Sun2005NADPHOI,
  title={NAD(P)H oxidase inhibition attenuates neuronal chronotropic actions of angiotensin II.},
  author={Chengwen Sun and Kathleen W Sellers and Colin Sumners and Mohan K. Raizada},
  journal={Circulation research},
  year={2005},
  volume={96 6},
  pages={659-66}
}
It is well established that the central cardiovascular effects of angiotensin II (Ang II) involve superoxide production. However, the intracellular mechanism by which reactive oxygen species (ROS) signaling regulates neuronal Ang II actions remains to be elucidated. In the present study, we have used neuronal cells in primary cultures from the hypothalamus and brain stem areas to study the role of ROS on the cellular actions of Ang II. Ang II increases neuronal firing rate, an effect mediated… CONTINUE READING

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