NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.

@article{Lafuente2000NADPHquinoneOR,
  title={NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.},
  author={Maria Jose Lafuente and Xavier Casterad and Manuel Tr{\'i}as and Carlos Ascaso and Rafael I. Molina and Antonio Ballesta and Shichun Zheng and John K. Wiencke and Amalia Lafuente},
  journal={Carcinogenesis},
  year={2000},
  volume={21 10},
  pages={1813-9}
}
NAD(P)H:quinone oxidoreductase (NQO1) is a polymorphic enzyme involved in the detoxification of potentially mutagenic and carcinogenic quinones. The homozygous C609T NQO1 genotype resulting in loss of reductase activity is found in 2-20% of individuals. In the present study, the NQO1-dependent risk for sporadic colorectal cancer (CRC) was studied in 247 incident CRC cases and 296 hospital-based controls recruited during 1996-1997. Four subgroups of cases were studied: (i) all CRCs; (ii) a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 14 references

Characterization of a polymorphism

  • W. A. Franklin, D. Ross
  • 1997

Molecular origin of (1999) 609 C to T polymorphism in NAD(P)H:quinone oxidoreductase

  • M. Steiner, M. Hillenbrand, +5 authors E. G. Rogan
  • 1997

Re: two inactivating processes are incomplete, CE-2,3-quinone

  • E. A. Rosvold, K. A. McGlynn, E. D. Lustbader, K. H. Buetow
  • 1995

A highly sensitive assay for mutant increased endogenous formation of N-nitroso compounds in the human

  • D. R. Jacobson, N. E. Mills
  • 1994

Similar Papers

Loading similar papers…