NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.

@article{Long2000NADPHquinoneO1,
  title={NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.},
  author={Delwin J. Long and Rebekah L. Waikel and Xiu Jun Wang and Laszlo Perlaky and Dennis R. Roop and Anil K. Jaiswal},
  journal={Cancer research},
  year={2000},
  volume={60 21},
  pages={5913-5}
}
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the metabolic detoxification of quinones and their derivatives. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity. C57BL6 NQO1-/- mice, deficient in NQO1 RNA and protein, were generated in our laboratory. To investigate the role of NQO1 in chemical carcinogenesis, the dorsal skin of NQO1-deficient (NQO1-/-) and wild-type (NQO1+/+) mice were treated with a single dose of benzo(a… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
56 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 56 extracted citations

Similar Papers

Loading similar papers…