NAD(P)H: quinone oxidoreductase polymorphism and lung cancer in Taiwan.

  title={NAD(P)H: quinone oxidoreductase polymorphism and lung cancer in Taiwan.},
  author={Pinpin Lin and Han Jia Wang and How Sung Lee and Shu Li Wang and Yu-Mei Hsueh and K. Joyce Tsai and C Y Chen},
  journal={Journal of toxicology and environmental health. Part A},
  volume={58 4},
Lung cancer is one of the leading causes of death in Taiwan since 1996. Genetic variation in metabolic activation or detoxification enzymes has been associated with the occurrence of lung cancer. NAD(P)H:quinone oxidoreductase (NQO1) enzyme is a cytosolic two-electron reductase thought to be involved in bioactivation and detoxification of environmental carcinogens. The possible association between NQO1 genetic polymorphism and lung cancer risk was examined among 95 male smokers without cancer… CONTINUE READING


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