NAD(P)H: quinone oxidoreductase (NQO1) gene polymorphism and schizophrenia.

  title={NAD(P)H: quinone oxidoreductase (NQO1) gene polymorphism and schizophrenia.},
  author={Hiroko Hori and Osamu Ohmori and Chima Matsumoto and Takahiro Shinkai and Jun - Ichi Sagara Shugo Nakamura},
  journal={Psychiatry research},
  volume={118 3},
NAD(P)H: quinone oxidoreductase (NQO1), an obligate two-electron reductase of quinones, prevents their participation in redox cycling and subsequent generation of reactive oxygen species (ROS). Reduced or negative activity of NQO1 would lead to an excess of neurotoxic compounds of cathecolamine o-quinones and ROS. Recently, there has been increasing evidence that catecholamine o-quinones and ROS might contribute to the development of schizophrenia. We investigated the genetic association… CONTINUE READING