NAD(+) treatment prevents rotenone-induced apoptosis and necrosis of differentiated PC12 cells.

@article{Hong2014NADTP,
  title={NAD(+) treatment prevents rotenone-induced apoptosis and necrosis of differentiated PC12 cells.},
  author={Yunyi Hong and Hui Zhen Nie and Danhong Wu and Xunbin Wei and Xianting Ding and Weihai Ying},
  journal={Neuroscience letters},
  year={2014},
  volume={560},
  pages={46-50}
}
Nicotinamide adenine dinucleotide (NAD(+)) plays critical roles in not only energy metabolism and mitochondrial functions, but also calcium homeostasis and immunological functions. It has been reported that NAD(+) administration can reduce ischemic brain damage. However, the mechanisms underlying the protective effects remain unclear. Because mitochondrial impairments play a key role in the cell death in cerebral ischemia, in this study we tested our hypothesis that NAD(+) can decrease… CONTINUE READING