NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise.

  title={NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise.},
  author={Amanda T. White and Simon Schenk},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={303 3},
The pyridine nucleotides, NAD(+) and NADH, are coenzymes that provide oxidoreductive power for the generation of ATP by mitochondria. In skeletal muscle, exercise perturbs the levels of NAD(+), NADH, and consequently, the NAD(+)/NADH ratio, and initial research in this area focused on the contribution of redox control to ATP production. More recently, numerous signaling pathways that are sensitive to perturbations in NAD(+)(H) have come to the fore, as has an appreciation for the potential… CONTINUE READING


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