NAC1, a cocaine-regulated POZ/BTB protein interacts with CoREST.

  title={NAC1, a cocaine-regulated POZ/BTB protein interacts with CoREST.},
  author={Laxminarayana Korutla and Ryan Degnan and Peijie Wang and Scott A. Mackler},
  journal={Journal of neurochemistry},
  volume={101 3},
In this report, CoREST was identified as a protein that interacts with NAC1. NAC1 is a cocaine-regulated Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad complex (POZ/BTB) repressor protein, which mediates interactions among several other transcriptional regulators. In the present study, an interaction between NAC1 and CoREST was detected in neuro-2A cells and HEK293T cells. We found that the POZ/BTB domain is necessary and sufficient for interaction with CoREST. Surprisingly, only one of… CONTINUE READING

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