NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum

@inproceedings{Zhang2012NACFA,
  title={NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum},
  author={Ying Zhang and Uta Berndt and Hanna Goelz and Arlette Tais and Stefan Oellerer and Tina W{\"o}lfle and Edith Fitzke and Sabine Rospert},
  booktitle={Molecular biology of the cell},
  year={2012}
}
Nascent polypeptide-associated complex (NAC) was initially found to bind to any segment of the nascent chain except signal sequences. In this way, NAC is believed to prevent mistargeting due to binding of signal recognition particle (SRP) to signalless ribosome nascent chain complexes (RNCs). Here we revisit the interplay between NAC and SRP. NAC does not affect SRP function with respect to signalless RNCs; however, NAC does affect SRP function with respect to RNCs targeted to the endoplasmic… CONTINUE READING

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