NAAG peptidase inhibitors and their potential for diagnosis and therapy

@article{Zhou2005NAAGPI,
  title={NAAG peptidase inhibitors and their potential for diagnosis and therapy},
  author={Jia Zhou and Joseph H Neale and Martin G. Pomper and Alan P. Kozikowski},
  journal={Nature Reviews Drug Discovery},
  year={2005},
  volume={4},
  pages={1015-1026}
}
Modulation of N-acetyl-L-aspartyl-L-glutamate peptidase activity with small-molecule inhibitors holds promise for a wide variety of diseases that involve glutamatergic transmission, and has implications for the diagnosis and therapy of cancer. This new class of compounds, of which at least one has entered clinical trials and proven to be well tolerated, has demonstrated efficacy in experimental models of pain, schizophrenia, amyotrophic lateral sclerosis, traumatic brain injury and, when… 

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