N6-methyladenosine residues in an intron-specific region of prolactin pre-mRNA.

  title={N6-methyladenosine residues in an intron-specific region of prolactin pre-mRNA.},
  author={Susan M. Carroll and Prema Narayan and F M Rottman},
  journal={Molecular and cellular biology},
  volume={10 9},
N6-methyladenosine (m6A) residues occur at internal positions in most cellular and viral RNAs; both heterogeneous nuclear RNA and mRNA are involved. This modification arises by enzymatic transfer of a methyl group from S-adenosylmethionine to the central adenosine residue in the canonical sequence G/AAC. Thus far, m6A has been mapped to specific locations in eucaryotic mRNA and viral genomic RNA. We have now examined an intron-specific sequence of a modified bovine prolactin precursor RNA for… CONTINUE READING
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