N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

  title={N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells},
  author={Yang Wang and Yue Li and Julia I. Toth and Matthew D. Petroski and Zhaolei Zhang and Jing Crystal Zhao},
  journal={Nature Cell Biology},
N6-methyladenosine (m6A) has been identified as the most abundant internal modification of messenger RNA in eukaryotes. m6A modification is involved in cell fate determination in yeast and embryo development in plants. Its mammalian function remains unknown but thousands of mammalian mRNAs and long non-coding RNAs (lncRNAs) show m6A modification and m6A demethylases are required for mammalian energy homeostasis and fertility. We identify two proteins, the putative m6A MTase, methyltransferase… CONTINUE READING
Highly Influential
This paper has highly influenced 26 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
172 Citations
35 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 172 extracted citations


Publications referenced by this paper.
Showing 1-10 of 35 references

Comprehensive analysis of mRNA methylation reveals enrichment in 3

  • Meyer, D K.
  • UTRs and near stop codons. Cell 149,
  • 2012
1 Excerpt

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

  • S Kishore
  • Nat. Methods
  • 2011

Similar Papers

Loading similar papers…