N6-adenyl arylation of DNA by aristolochic acid II and a synthetic model for the putative proximate carcinogen.

@article{Pfau1991N6adenylAO,
  title={N6-adenyl arylation of DNA by aristolochic acid II and a synthetic model for the putative proximate carcinogen.},
  author={Wolfgang Pfau and Heinz Hans Schmeiser and Manfred Wiessler},
  journal={Chemical research in toxicology},
  year={1991},
  volume={4 5},
  pages={581-6}
}
Aristolochic acid II (AAII), one of the major components of the carcinogenic plant extract aristolochic acid, is known to be mutagenic and to form DNA adducts in vitro and in vivo. The major fluorescent DNA adduct formed upon xanthine oxidase mediated reduction in the presence of calf thymus (CT-) DNA or deoxyadenosine was isolated by means of preparative HPLC and identified by fluorescence, UV/vis absorbance, and 1H NMR spectroscopy as 7-(deoxy-adenosin-N6-yl)aristolactam II. As a model… CONTINUE READING

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