N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.

@article{Biondi2010N348IIH,
  title={N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.},
  author={Mia J Biondi and Greg L. Beilhartz and Suzanne U McCormick and Matthias G{\"o}tte},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 35},
  pages={26966-75}
}
Drug resistance-associated mutations in HIV-1 reverse transcriptase (RT) can affect the balance between polymerase and ribonuclease H (RNase H) activities of the enzyme. We have recently demonstrated that the N348I mutation in the connection domain causes selective dissociation from RNase H-competent complexes, whereas the functional integrity of the polymerase-competent complex remains largely unaffected. N348I has been associated with resistance to the non-nucleoside RT inhibitor (NNRTI… CONTINUE READING

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NUMBER 35 JOURNAL OF BIOLOGICAL CHEMISTRY 26975 at U iv of St A nrew s on M arch 4, 2015 hp://w w w .jb.org/ D

  • V. von Wyl, M. Ehteshami, +10 authors H. F. Günthard
  • J. Infect
  • 2010

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