N1-acetyl-N2-formyl-5-methoxykynuramine is a product of melatonin oxidation in rats.

  title={N1-acetyl-N2-formyl-5-methoxykynuramine is a product of melatonin oxidation in rats.},
  author={Stanislav V Rozov and Elena V. Filatova and Alexandr A Orlov and Anvara V Volkova and Alexand R A Zhloba and Eduard L Blashko and Nikita V. Pozdeyev},
  journal={Journal of pineal research},
  volume={35 4},
The product of melatonin oxidation, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), was synthesized and a method for its determination in biological samples was developed. High performance liquid chromatography (HPLC) with fluorescence detection provided good sensitivity and selectivity. Wavelengths of 350 and 480 nm were used for excitation and emission, respectively. Serum and retinal homogenates were extracted with chloroform prior to analysis by HPLC. Endogenous AFMK was detected in the… CONTINUE READING


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