N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

@inproceedings{Wirths2017NtruncatedAP,
  title={N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models},
  author={Oliver Wirths and Susanne Walter and Inga Kraus and Hans Wolfgang Klafki and Martina Stazi and Timo Oberstein and Jorge Ghiso and Jens Wiltfang and Thomas A. Bayer and Sascha Weggen},
  booktitle={Alzheimer's Research & Therapy},
  year={2017}
}
BackgroundThe deposition of neurotoxic amyloid-β (Aβ) peptides in plaques in the brain parenchyma and in cerebral blood vessels is considered to be a key event in Alzheimer’s disease (AD) pathogenesis. Although the presence and impact of full-length Aβ peptides such as Aβ1–40 and Aβ1–42 have been analyzed extensively, the deposition of N-terminally truncated Aβ peptide species has received much less attention, largely because of the lack of specific antibodies.MethodsThis paper describes the… CONTINUE READING

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