N-terminus of MAP2C as a neurosteroid-binding site.

  title={N-terminus of MAP2C as a neurosteroid-binding site.},
  author={Kaori Mizota and Hiroshi Ueda},
  volume={19 15},
The kinetics of neurosteroid binding to recombinant human microtubule-associated protein 2C (rhMAP2C) and neurosteroid regulation of MAP2C-stimulated tubulin assembly were studied. In a quartz crystal microbalance assay, progesterone-BSA at 1-10 nM showed concentration-dependent binding to rhMAP2C, and this binding was competitively inhibited by pregnenolone or progesterone. However, no progesterone-BSA binding to N-terminal 71 amino acid residues rhMAP2C was found. In an rhMAP2C-stimulated… CONTINUE READING

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