N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization.


ROCK-I (Rho-associated kinase 1) is a serine/threonine kinase that can be activated by RhoA and inhibited by RhoE. ROCK-I has an N-terminal kinase domain, a central coiled-coil region and a RhoA-binding domain near the C-terminus. We have previously shown that RhoE binds to the N-terminal 420 amino acids of ROCK-I, which includes the kinase domain as well… (More)
DOI: 10.1042/BJ20071342


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