N-terminal regions of Mps1 kinase determine functional bifurcation

@inproceedings{Araki2010NterminalRO,
  title={N-terminal regions of Mps1 kinase determine functional bifurcation},
  author={Yasuhiro Araki and Linda Gombos and Suellen P.S. Migueleti and Lavanya Sivashanmugam and C. Calokerinos Antony and Elmar Schiebel},
  booktitle={The Journal of cell biology},
  year={2010}
}
Mps1 is a conserved kinase that in budding yeast functions in duplication of the spindle pole body (SPB), spindle checkpoint activation, and kinetochore biorientation. The identity of Mps1 targets and the subdomains that convey specificity remain largely unexplored. Using a novel combination of systematic deletion analysis and chemical biology, we identified two regions within the N terminus of Mps1 that are essential for either SPB duplication or kinetochore biorientation. Suppression analysis… CONTINUE READING

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