N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone.

@article{Bhasin2009NterminalPO,
  title={N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone.},
  author={Shalender Bhasin and E. J. He and Miwa Kawakubo and E. Todd Schroeder and Kevin E Yarasheski and Gregory J. Opiteck and Alise S. Reicin and Fabian Chen and Raymond Lam and Jeffrey A. Tsou and Carmen Castaneda-Sceppa and Ellen F. Binder and Stanley Paul Azen and Fred R. Sattler},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 11},
  pages={4224-33}
}
CONTEXT Biomarkers that predict musculoskeletal response to anabolic therapies should expedite drug development. During collagen synthesis in soft lean tissue, N-terminal propeptide of type III procollagen (P3NP) is released into circulation. We investigated P3NP as a biomarker of lean body mass (LBM) and muscle strength gains in response to testosterone and GH. DESIGN Community-dwelling older men received GnRH agonist plus 5 or 10 g testosterone gel plus 0, 3, or 5 microg recombinant human… CONTINUE READING
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