N-terminal prodomain of Pfs230 synthesized using a cell-free system is sufficient to induce complement-dependent malaria transmission-blocking activity.

@article{Tachibana2011NterminalPO,
  title={N-terminal prodomain of Pfs230 synthesized using a cell-free system is sufficient to induce complement-dependent malaria transmission-blocking activity.},
  author={Mayumi Tachibana and Yimin A. Wu and Hideyuki Iriko and Olga Muratova and Nicholas J Macdonald and Jetsumon Sattabongkot and Satoru Takeo and Hitoshi Otsuki and Motomi Torii and Takafumi Tsuboi},
  journal={Clinical and vaccine immunology : CVI},
  year={2011},
  volume={18 8},
  pages={1343-50}
}
The aim of a malaria transmission-blocking vaccine is to block the development of malaria parasites in the mosquito and thus prevent subsequent infection of the human host. Previous studies have demonstrated that the gametocyte/gamete surface protein Pfs230 can induce transmission-blocking immunity and have evaluated Escherichia coli-produced Pfs230 as a transmission-blocking vaccine candidate. In this study, we used the wheat germ cell-free expression system to produce N-terminal fragments of… CONTINUE READING

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