N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro.

@article{Lipps2016NterminalFO,
  title={N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro.},
  author={Christoph Lipps and Jenine H Nguyen and Lukas Pyttel and Thomas L Lynch and Christoph Liebetrau and Ganna Aleshcheva and Sandra Voss and Oliver Doerr and Holger M. Nef and Helge Moellmann and C. W. Hamm and Sakthivel Sadayappan and Christian Troidl},
  journal={Journal of molecular and cellular cardiology},
  year={2016},
  volume={99},
  pages={
          47-56
        }
}
Myocardial infarction (MI) leads to loss and degradation of contractile cardiac tissue followed by sterile inflammation of the myocardium through activation and recruitment of innate and adaptive cells of the immune system. Recently, it was shown that cardiac myosin binding protein-C (cMyBP-C), a protein of the cardiac sarcomere, is degraded following MI, releasing a predominant N-terminal 40-kDa fragment (C0C1f) into myocardial tissue and the systemic circulation. We hypothesized that early… CONTINUE READING
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