N-terminal fatty acylation of transducin profoundly influences its localization and the kinetics of photoresponse in rods.

Abstract

N-terminal acylation of the alpha-subunits of heterotrimeric G-proteins is believed to play a major role in regulating the cellular localization and signaling of G-proteins, but physiological evidence has been lacking. To examine the functional significance of N-acylation of a well understood G-protein alpha-subunit, transducin (G alpha(t)), we generated… (More)

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