N-terminal determinants of human cytomegalovirus IE1 protein in nuclear targeting and disrupting PML-associated subnuclear structures.

Abstract

The 72-kDa IE1 protein of human cytomegalovirus disrupts PML-associated subnuclear structures (PODs) by inducing PML desumoylation. This process correlates with the functions of IE1 in transcriptional regulation and efficient viral replication. Here, we defined the N-terminal regions of IE1 required for nuclear targeting and POD-disrupting activity… (More)

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@article{Lee2007NterminalDO, title={N-terminal determinants of human cytomegalovirus IE1 protein in nuclear targeting and disrupting PML-associated subnuclear structures.}, author={H Lee and Yong Ho Huh and Young-Eui Kim and Karim Lee and Sunyoung Kim and Jin-Hyun Ahn}, journal={Biochemical and biophysical research communications}, year={2007}, volume={356 2}, pages={499-504} }