N-terminal chromogranin-derived peptides as dilators of bovine coronary resistance arteries.

@article{Brekke2002NterminalCP,
  title={N-terminal chromogranin-derived peptides as dilators of bovine coronary resistance arteries.},
  author={Johan Fredrik Brekke and George J Osol and Karen B. Helle},
  journal={Regulatory peptides},
  year={2002},
  volume={105 2},
  pages={93-100}
}
N-terminal peptides of chromogranin A and B (CGA and CGB) were compared for dilator responses in isolated bovine coronary arteries (bCoA), measuring diameter changes as a function of pressure. bCoA developed and maintained myogenic tone (MYT) at approximately 20% from 50 to 150 mm Hg. In contrast to CGB(1-40), CGA(1-40) and CGA(1-76) (VS-I) both displayed significant intrinsic vasodilator effects. CGA(1-40) reduced myogenic reactivity from 70 to 150 mm Hg (p<0.05, n=6). At 75 mm Hg, CGA(1-40… CONTINUE READING