N-terminal Halves of Rat H+/Peptide Transporters Are Responsible for Their Substrate Recognition

  title={N-terminal Halves of Rat H+/Peptide Transporters Are Responsible for Their Substrate Recognition},
  author={Tomohiro Terada and Hideyuki Saito and Kyoko Sawada and Yukiya Hashimoto and Ken-ichi Inui},
  journal={Pharmaceutical Research},
Purpose. Peptide transporters PEPT1 and PEPT2 differ substantiallyin their substrate affinity and recognition. The aim of this study is todefine the structural domains which influence the functionalcharacteristics of both transporters Methods. Two kinds of chimeric peptide transporters (PEPT-N1C2and PEPT-N2C1) were constructed, and their functional characteristicswere compared with those of wild-type transporters in stabletransfectants. Results. PEPT-N1C2, the N-terminal half of rat PEPT1 and… CONTINUE READING

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