N-sulphoconjugation of alicyclic, alkyl- and aryl-amines in vivo and in vitro.

@article{Iwasaki1986NsulphoconjugationOA,
  title={N-sulphoconjugation of alicyclic, alkyl- and aryl-amines in vivo and in vitro.},
  author={Kazuhide Iwasaki and Toshifumi Shiraga and Kazuo Noda and Keiya Tada and Hiroshi Noguchi},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1986},
  volume={16 7},
  pages={651-9}
}
Radioactive 35S in 3'-phosphoadenosine 5'-phosphosulphate was incorporated into alicyclic, alkyl- and aryl- amines in the presence of hepatic 105 000 g supernatants of female rats. 4-Phenylpiperazine, 4-phenyl-1,2,3,6-tetrahydropyridine (PTHP), 1,2,3,4-tetrahydroisoquinoline, N-methylbenzylamine, desmethylzotepine and desmethylzimeldine showed the highest conjugation with 35SO3 among the amines tested. Incorporation of 35SO3 into alicyclic and alkyl-amines was higher at pH 10.0 than at pH 7.4… CONTINUE READING

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